Role of Vitamin-D and Oxidative Stress in Polycystic Ovarian Syndrome with Rheumatoid Arthritis
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Aim and objectives: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder. Metabolic disturbances including hyperinsulinemia, dyslipidemia and insulin resistance, are common features in the majority of PCOS women. Women with PCOS may also be at increased risk of vitamin D deficiency. Several studies have reported that lower vitamin D levels are associated with increased risk of insulin resistance and metabolic disturbance among women with PCOS . The objective of the study was to evaluate the relationship between vitamin D and oxidative stress in pcos with RA
Materials And Methods : The study includes 20 healthy control women, and 20 were with PCOS with rheumatoid arthritis .Total sample size was 40. Vitamin D total is estimated by chemiluminescent immunoassay and to assess oxidative stress, serum Malonyldialdehyde (MDA) was done by thiobarbituric acid method and antioxidant level was assessed by estimation of serum vitamin C by dinitrophenyl hydrazine method.
Results: There was a decrease of vitamin -D in PCOS with RA (30.5 ±1.6), when compared with control(59.8 ±2.8). It was statistically significant (P<0.001). There was a decrease in vitamin -C in PCOS with RA (0.7 ±0.07) when compared with controls(1.1± 0.08). It was statistically significant (P<0.001). There was a increase of MDA in PCOS with RA, (9.0± 0.6) when compared with control (3.8± 0.2). It was statistically significant (P<0.001).
Conclusion: Low levels of Vitamin D deficiency in PCOS with RA patients is associated with inflammation which leads to Increased oxidative stress status , which may lead to connective tissue degradation leading to joint and periarticular deformities in rheumatoid arthritis.
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