Synthesis and Antibacterial Activity of 4,4’-(Arylmethylene)Bis(3-Methyl-1- Phenyl-1H-Pyrazol-5-Ol) Derivatives in Presence Ce(SO4)2.4H2O as a Catalyst Under Solvent free Condition using Ultrasonication Technique

DATE PUBLISHED
February 14, 2020
SECTION
Articles

Abstract

Mixture of aromatic aldehyde(1 mmol) and 1-phenyl-3-methyl-5-pyrazolone (2 mmol) in H2O–EtOH (1:1, 5 mL) at heating condition, was stirred thoroughly in the presence of a catalytic amount of Ce(SO4)2.4H2O (10 mg, 2.5 mol%) to afford 4,4’-(arylmethylene)bis(3-methyl-1-phenyl-pyrazol-5-ols) in excellent yields.

The synthesized derivatives were subjected for anti-bacterial activity using ciprofloxacin as standard drug against S. aureus and Pseudomonas aeruginosa using agar cup plate method. All the derivatives showed good antibacterial activity. The salient features of this method include simple procedure, mild conditions, easy purification, moderate to good yields of products and high generality.

Keywords

4,4’-(arylmethylene)bis(3-methyl-1- phenyl-1H-pyrazol-5-ol) derivatives, ultrasonication technique

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Author Details

Rajiv V Khobare

Ramkrushna P Pawar

Khandu D Warad

Amit P Tayde

Chandrakant B. Mane