Antimicrobial Potential of Some Plant Extracts against Multidrug Resistant Pathogenic Bacteria: Staphylococcus Aureus and Klebsiella Pneumonia

February 19, 2019


Plants have been extensively studied as alternative agents for prevention and treatment of infectious diseases. The present work evaluates the inhibitory efficacy of different extracts prepared from seven plant species (Erica lusitanica, Hypericum canariensis, H. inodorum, H. perforatum, Paeonia broteri, Quercus faginea subsp. broteroi and Sanguisorba hybrida) against five standard strains and clinical isolates of human pathogenic bacteria (Staphylococcus aureus and Klebsiella pneumonia). In vitro antibacterial activity was evaluated using the serial broth microdilution method.

The polar extracts were more effective against both Gram (+) and Gram (–) strains.  The MeOH and H2O extracts of S. hybrida (leaves and stems), P. broteri (leaves) and H. perforatum (leaves and stems), showed high-moderate antibacterial activity against all the five multidrug resistant (MDR) bacteria tested. These plant species appear as potential leads against MDR bacteria.




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Author Details

Madureira A M

  • iMed Universidade de Lisboa, Faculdade de Farmácia, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003, Lisboa, Portugal.
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Jordão L

  • Departamento de Saúde Ambiental, Unidade de Investigação e Desenvolvimento, Av Padre Cruz, 1649-016, Lisboa, Portugal
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Ferreira P

  • Departamento de Saúde Ambiental, Unidade de Investigação e Desenvolvimento, Av Padre Cruz, 1649-016, Lisboa, Portugal
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Duarte A

  • iMed Universidade de Lisboa, Faculdade de Farmácia, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003, Lisboa, Portugal
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Teixeira G

  • Center for Ecology, Evolution and Environmental Changes (CE3C), Faculdade de Ciências - C2, Univ. Lisboa, Cpo. Grande, 1749-016, Lisboa, Portugal. Faculdade de Farmácia, Univ. Lisboa, Av. Prof. Gama Pinto, 1649-003, Lisboa, Portugal.
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