The homeobox NKX and Neoplasms in Digestive system: a systematic review.
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The incidence of digestive system neoplasms is increasing over these years due to the limitation of prompt diagnosis and effective treatment. Homeobox genes are usually associated with development of cancer. Previous studies indicate that homeobox NKX transcription factors are partly involved in the development and progression of tumors in gastrointestinal tract. To summarize the different impact of NKX genes have on the digestive system, the interrelationship between each NKX genes and gastric-derived tumors is analyzed as much detail as possible. The results turn out that some of NKX genes may be used as a target to distinguish the primary site of cancer, or as a biomarker to predict the therapeutic effect and survival which is instructive and meaningful to the future medical managements. This review is a systematic synopsis of research on the homeobox genes NKX and digestive system neoplasms, with the focus on their functions and clinical significance.
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