Blood Cells Positive Increase Regulated By Haemopoietic Stimulating Plasma Antimalarials Concentration

Antimalarials, concentration, haematopoietic , potentials

Authors

  • DR. Jimmy E. O. Department Of Physiology, Faculty of Basic Medical Sciences, University of Uyo, Akwa Ibom State - Nigeria
April 20, 2017

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Effects of varied plasma concentrations of amalar, chloroquine, cotecxin, fansidar and lapdap on blood cells and its parameters were investigated in twenty four albino rats for 28 days. There was significant difference in the plasma concentration of various antimalarials, amalar; 5.9611mg/L, chloroquine; 3.0140mg/L, cotecxin,; 1.6571mg/L, fansidar; 10.704mg/L and lapdap; 0.9601mg/L, (P<0.05). Fansidar showed the highest plasma concentration amongst all the drugs. Despite these plasma variations, chloroquine increased red blood cells, haemoglobin and packed cell volume than other drugs, (P<0.05) lapdap increased white blood cells count than others, (P<0.05) whereas, cotecxin increased platelet counts than other drugs (P<0.05). Chloroquine is found in the study to be very beneficial to blood cells development. It is also shown that the increase in blood cells and its parameters is not a function of the various increase concentration of the antimalarials but it varied haemopoietic stimulating potentials.